Lions can win
I think they will and here's why:
They are due. Of course, they've been due for a while and making the playoffs is a nice step forward after a dozen years away, but it would be a surprising jump to win a game and I think they will do so.
The Saints have blown it before and they'll blow it again. They had a nice progressive run, losing in NFC finals before winning the Super Bowl after a history that was worse than the Lions. Then they stumbled in Seattle. Another roadbump is possible.
It's Saturday night. Strange stuff happens. The full moon hits at 12:34 a.m. Sunday, an hour or so after the Lions shock the Saints. I wanted to say shock the NFL, but everyone knows the Lions can score and everyone knows that anything can happen in the NFL. nuff said.